郭非凡 简历 - 名人简历

该研究组主要是通过生化和分子细胞生物学方法，在细胞和动物水平阐明遗传和营养调节的诸如肥胖、糖尿病和脂肪肝等代谢疾病的分子机制。研究集中在中枢神经系统和外周神经系统对亮氨酸缺乏引起的脂肪代谢异常的研究上。该研究将对肥胖、糖尿病和脂肪肝的营养学干预和治疗提供依据和可能。

Du Y, Meng Q, Zhang Q, Guo F*. Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT.Amino Acids. 2011 Oct 21. [Epub ahead of print]

Cheng Y#, Zhang Q# (co-author), Meng Q, Xia T, Huang Z, Wang C, Liu B, Chen S, Xiao F, Du Y, and Guo F*. Leucine Deprivation Stimulates Fat Loss via Increasing CRH Expression in The Hypothalamus and Activating The Sympathetic Nervous System.Molecular Endocrinology. 2011, 25(9):1624-1635.

Li H, Meng Q, Xiao F, Chen S, Yu J, Wang C, and Guo F*. ATF4 deficiency protects mice from high-carbohydrate diet-induced liver steatosis.Biochemical Journal. 2011, 438(2):283-289.

Xiao F, Huang Z, Li H, Yu J, Wang C, Chen S, Meng Q, Cheng Y, Gao X, Li J, Liu Y, and Guo F*. Leucine Deprivation Increases Hepatic Insulin Sensitivity Via GCN2/mTOR/S6K1 and AMPK Pathways.Diabetes. 2011, 60: 746-756.

Zhang Q, Li H and Guo F*. Amygdala, an important regulator for food intake (Invited Review).Frontiers in Biology. 2011, 6: 82-85.

Cheng Y#, Meng Q# (co-author), Wang C, Li H, Huang Z, Chen S, Xiao F, Guo F*. Leucine deprivation decreases fat mass by stimulation of lipolysis in WAT and upregulation of UCP1 in BAT.Diabetes. 2010, 59: 17-25.

Wang C, Huang Z, Du Y, Cheng Y, Chen S and Guo F*. ATF4 regulates lipid metabolism and thermogenesis.Cell Research. 2010, 20:174-184.

Guo F, Cavener D. The GCN2 eIF2α Kinase Regulates Fatty-Acid Homeostasis in the Liver during Deprivation of an Essential Amino Acid.Cell Metabolism. 2007, 5:103-114.

Ebihara T, Guo F, Zhang L, Kim JY, Saffen D. Muscarinic acetylcholine receptors stimulate Ca2+ influx in PC12D cells predominantly via activation of Ca2+ store-operated channels.The Journal of Biochemistry. 2006, 139: 449-458.

Zhang L, Guo F, Kim J, Saffen D. Muscarinic Acetylcholine Receptors Activate TRPC6 Channels in PC12D Cells via Ca2+ Storeu2013Independent Mechanisms.The Journal of Biochemistry. 2006, 139: 459-470.

吕子全,郭非凡*. 氨基酸感应与糖脂代谢调控的研究进展.生命科学. 2013, 25: 152-157.

吕子全,郭非凡*. 内源性代谢分子——亮氨酸调节机体生理功能.生理科学进展. 2012, 43: 337-340.

2020年3月6日，荣获上海市巾帼创新奖，同时荣获上海市三八红旗手标兵称号。